ABSTRACT

Aims:

To study the association of daily coffee consumption with all-cause and cardiovascular (CV) mortality and major CV outcomes. In a subgroup of participants who underwent cardiovascular magnetic resonance (CMR) imaging, we evaluated the association between regular coffee intake and cardiac structure and function.

Methods:

UK Biobank participants without clinically manifested heart disease at the time of recruitment were included. Regular coffee intake was categorized into 3 groups: zero, light-to-moderate (0.5-3cups/day) and high (>3 cups/day). In the multivariate analysis, we adjusted for the main CV risk factors.

Results:

‍We included 468,629 individuals (56.2 ± 8.1years, 44.2% male), 22.1% did not consume coffee on a regular basis, 58.4% had0.5-3 cups per day and 19.5% had >3 cups per day. Compared to non-coffee drinkers, light-to-moderate (0.5-3 cups per day) coffee drinking was associated with lower risk of all-cause mortality (multivariate HR = 0.88, 95%CI :0.83-0.92; p < 0.001) and CV mortality (multivariate HR = 0.83, 95%CI :0.74-0.94; p = 0.006), and incident stroke (multivariate HR = 0.79, 95%CI :0.63-0.99 p = 0.037) after a median follow-up of 11 years. CMR data were available in 30,650 participants. Both light-to-moderate and high coffee consuming categories were associated with dose-dependent increased left and right ventricular end-diastolic, end-systolic and stroke volumes, as well as greater left ventricular mass.

Conclusion:

‍Coffee consumption of up to 3 cups per day was associated with favorable CV outcomes. Regular coffee consumption was also associated with a likely healthy pattern of CMR metrics in keeping with the reverse of age-related cardiac alterations.