ABSTRACT

Background and Aims:
Association of coffee consumption with estimated glomerular filtration rate (eGFR) change in the general population is inconclusive. We investigated associations of coffee consumption with annual eGFR change in a large Dutch population-based study.  

Methods and Results:
This study was performed in 78,346 participants free of CKD in the population-based Lifelines Cohort Study. Coffee consumption was assessed at baseline using food frequency questionnaires. Outcomes were annual eGFR change and a composite kidney outcome (defined as eGFR 20% 40 eGFR decline). Multivariable linear and logistic regression analyses were used to evaluate the associations of coffee consumption (categories and cups/day) with kidney outcomes. Overall, 90% of the participants drank coffee daily and 36% drank >2-4 cups/day. Unadjusted mean ±SD annual eGFR change ranged from -2.86±2.96 (for non-coffee drinkers) to -2.35±2.62 (for participants consuming >6 cups/day) mL/min per 1.73m2 . During 3.6±0.9 years follow-up, 11.1% of participants reached the composite kidney outcome. As compared to non-coffee drinkers, higher coffee consumption was associated with less annual eGFR decline in multivariable models 48 (β [95% CIs] ranged from 0.15 [0.07, 0.22] for >0-2 cups/day to 0.29 [0.20, 0.38] 49 for >6 cups/day, P-trend ≤0.001). Consumption of one more cup of coffee per day was associated with a 3% lower risk of the composite kidney outcome (OR [95%CI], 0.97 [0.96,0.99). The inverse association was more pronounced in a subgroup of individuals with diabetes.

Conclusion:
Coffee consumption was inversely associated with annual eGFR change and CKD risk in a large Dutch population-based cohort.

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