15th Edition - 2015

Welcome to the latest edition of the Coffee & Health quarterly news bulletin. Below you will find information on the latest published research, topic updates and new information resources.

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EXPERT COMMENT – Dr Karen Ritchie, expert in cognitive decline and neurodegenerative disorders

Dr Karen Ritchie of the French National Institute for Health and Medical Research (INSERM) specializes in research on neurodegenerative conditions, public health and healthcare improvement. During the Global Coffee Forum held in Milan, she presented some of her latest clinical research on the relationship between coffee consumption and cognitive decline, suggesting that lifelong, regular coffee consumption may be beneficial to the prevention of cognitive decline and dementia. Click here to read.


ISIC participated in the Global Coffee Forum, a two-day event held in Milan from the 30 September to the 1 October, organized in conjunction with EXPO. Alok Jha, journalist, author, and science correspondent at ITV News hosted a panel discussion on the theme of “Coffee and Healthy Ageing”, with expert speakers Dr Karen Ritchie, whose research interests are outlined above, and Dr Carlo La Vecchia, Professor of Epidemiology at the School of Medicine at the University of Milan and leading authority in cancer aetiology and epidemiology. The topics covered included coffee and cognitive decline, diabetes, and cardiovascular health, followed by an interactive Q&A session. You can find out more here.


Alzheimer’s Disease is a neurodegenerative condition, and the most common form of dementia. Close to one person in twenty over the age of 65 indeed suffers from Alzheimer’s Disease. There is a growing body of literature that considers the role that coffee consumption may play with regard to developing dementia. In their majority, epidemiological studies to date suggest that lifelong moderate caffeinated coffee consumption may reduce the risk of developing Alzheimer’s Disease. At the occasion of World Alzheimer’s Day on September 21, the Institute for Scientific Information on Coffee issued a report highlighting the latest research on the topic.

To read the full report, click here.


Along with improvements in medical interventions, significant developments in research have the power to reduce the risk of mortality through cardiovascular disease (CVD) in Europe. On September 29 for World Heart day, ISIC issued a news alert covering the latest research with regards to coffee consumption and cardiovascular health. Existing research suggests that moderate coffee consumption (3-5 cups per day) may provide protection against CVD mortality risk.

To read more on coffee consumption and risk of stroke, click here.


We regularly publish abstracts of the latest research papers on coffee and health, so you can see at a glance what's new in this area. If you haven’t had the chance to catch up with the latest research, you can find these on the Coffee & Health website. You can now also view these abstracts by topic, as well as by date.

Recent studies published include:

Coffee consumption and risk of atrial fibrillation

This study looked at whether coffee consumption affects the risk of developing atrial fibrillation by analysing two prospective cohorts (41,881 men in the Cohort of Swedish Men and 34,594 women in the Swedish Mammography Cohort who had provided information on coffee consumption in 1997 and were followed up for 12 years) and summarised the available evidence using a meta-analysis. The researchers found no evidence that coffee consumption is associated with increased risk of atrial fibrillation.
S C Larsson et al, 2015. Coffee consumption is not associated with increased risk of atrial fibrillation: results from two prospective cohorts and a meta-analysis, BMC Medicine, published online ahead of print.
To find out more about coffee and atrial fibrillation, click here

Coffee and caffeine consumption and depression

368,900 participants from eleven studies were included in this meta-analysis of the relationship between coffee consumption and depression, and caffeine consumption and depression. Clinical depression is a genuine illness, with symptoms including constant tiredness, sleep disruption, and loss of appetite. Both coffee and caffeine consumption were significantly associated with a decreased risk. The dose-response analysis showed evidence of a linear association between coffee consumption and depression: the risk of depression decreased by 8 percent for each cup/day augmentation in coffee intake.
L Wang et al, 2015, Coffee and caffeine consumption and depression: a meta-analysis of observational studies, Australian and New Zealand Journal of Psychiatry, published online ahead of print.
More information on coffee and mood can be found here

Coffee consumption and risk of endometrial cancer

This meta-analysis of over 1,500,000 participants evaluated the dose-response relationship between coffee consumption and endometrial cancer risk. Variations in the risk of developing endometrial cancer were found to be linked to both coffee and caffeine intake. The findings indicate that for every cup of caffeinated coffee consumed per day, the risk of endometrial cancer decreases by 7 percent. BMI and history of hormone therapy are found to influence this result.
O Zhou et al, 2015. Coffee consumption and risk of endometrial cancer: a dose-response meta-analysis of prospective cohort studies, Scientific Reports, published online ahead of print.
To find out more about coffee and endometrial cancer click here

Coffee consumption and Alzheimer's Disease

323 articles were included in this meta-analysis, of which the aim is to identify factors affecting the risk of developing Alzheimer’s disease. Coffee was identified, along with vitamins E and C, and folate as a dietary factor with a protective role on the incidence of Alzheimer’s. Other influencing factors on the development of the disease include certain medical and biochemical exposures, psychological condition, and pre-existing diseases and lifestyle habits.
W Xu et al, 2015. Meta-analysis of modifiable risk factors for Alzheimer’s Disease, Journal of Neurology, Neurosurgery and Psychiatry, published online ahead of print.
To read more about coffee and neurodegenerative disorders, click here

Coffee consumption and colon cancer recurrence

Existing literature suggests that dietary and lifestyle factors can affect the rate of colon cancer recurrence. Cox proportional hazards regression - a statistical model frequently used to produce a baseline survival curve – was used to examine the relationship between coffee, nonherbal tea, and caffeine intake with cancer recurrence and mortality. The findings revealed that there is no association between coffee and overall gastric cancer risk; however, there may be an association between coffee consumption and risk of gastric cardia cancer.
B J Guercio et al, 2015, Coffee Intake, Recurrence, and Mortality in Stage III Colon Cancer: Results from CALGB 89803 (Alliance). Journal of Clinical Oncology, published online ahead of print.
More information on coffee and colocteral cancer can be found here

Coffee consumption and risk of gallstone disease

This large scale meta-analysis spans 227,749 participants and 11,477 cases of gallstone disease. In contrast with previous research, which had not established a clear relationship between coffee consumption and the risk of gallstone disease, this study found that coffee consumption is significantly associated with a reduction in the risk of gallstone disease.
Y-P Zhang et al, 2015, Systematic review with meta-analysis: coffee consumption and the risk of gallstone disease, Alimentary Pharmacology & Therapeutics, published online ahead of print.
More information on coffee and gallstones can be found here

Coffee consumption and cardiovascular health

To get a better understanding of the effects of coffee consumption on cardiovascular health, this study conducted a Medline search of the English language literature from 2010 to early 2015, and 25 pertinent reports with information on the effects of coffee drinking, and concluded that coffee is safe to drink by both normal subjects and by those with pre-existing CVDs and hypertension.
S G Chrysant, 2015, Coffee Consumption and Cardiovascular Health, American Journal of Cardiology, published online ahead of print.
You can read more about coffee consumption and cardiovascular health here


Coffee is always a popular topic of interest in the media. We’ve collated media highlights from the last quarter which feature coffee research. In many cases, these stories reference a single new study or review. Where available, please follow the links to relevant sections on the Coffee & Health website.

Coffee consumption and its effect on the human circadian clock

Previous research has suggested a link between high levels of caffeinated coffee consumption and sleep disruption in some individuals, and new research published in Science Translational Medicine has now analysed more precisely how caffeine consumption affects the internal body clock. Results show that drinking the equivalent of a double expresso 3 hours before going to sleep could delay the body clock, or circadian rhythm, by 40 minutes. Some participants were given caffeine pills equivalent to two shots of coffee before going to bed and the rest were given placebos. In subjects who had been given caffeine, melatonin levels rose around 40 minutes later compared with those who had been given a placebo. Highlights include BBC News, The Guardian, The Daily Telegraph, The Times, The Daily Mail, Augsburger Allgemeine and Liberation.

For more information on effects of caffeine intake on sleep, click here

Coffee consumption and risk of atrial fibrillation

A new study published in the open access journal BMC Medicine reports a lack of association between coffee consumption and increased risk of atrial fibrillation, a heart condition causing an irregular and abnormally fast heart rate. The meta-analysis comprised 41,881 men and 34,594 women who reported, in 1997, how many cups of coffee they consumed and were subsequently followed up for 12 years. Even in more extreme levels of coffee consumption, no evidence was found of an association with higher incidence of atrial fibrillation. Coverage of the results appeared over several weeks and included Fox News, U.S. News & World Report, International Business Times, Yahoo! News, Medical News Today, MSN, and Sueddeutsche Zeitung.

For more information on coffee and atrial fibrillation, click here

Coffee consumption and risk of cardiovascular events in young adults with mild hypertension

Research presented at the Congress of the European Society of Cardiology held in London from the 29 August to the 2nd September generated significant coverage. The longitudinal study of health data for a group of approximately 1,200 adults aged 18 to 45 found an association between coffee consumption and an increase in the risk of heart attack in young adults with high blood pressure, or known heart disease. The findings generated widespread international coverage, including US News & Health Report, Medical News Today, Zee News, Tribune India, Sci Feeds, Vlad Time, and Palo.

For more information on coffee and cardiovascular health, click here

Moderate coffee consumption and its protective effect against bowel cancer recurrence

Cancer remains a popular topic in the media, considering its prevalence internationally, and new research published in the Journal of Clinical Oncology has found evidence of inverse association between coffee consumption and stage 3 colon cancer recurrence. The study reported that patients who consumed four or more cups of coffee a day were 42% less likely to see their cancer return than non-coffee drinkers. This effect was found to be dose-responsive, increasing as more of the beverage was consumed. Coverage of this study was overwhelmingly positive, with top tier publications including Huffington Post, Irish Examiner, Belfast Telegraph, The Hill, The Financial Express, Examiner, France TV info, Le Figaro, Le Monde du Tabac and South China Morning Post.

More information of coffee consumption and cancers of the digestive tract can be found here on our website.

Coffee consumption may influence the risk of mild cognitive impairment

Regularly drinking one to two cups of coffee each day is associated with a significant reduction in the risk of mild cognitive impairment (MCI) compared to people who never or rarely consume coffee, according to a study published in the Journal of Alzheimer’s Disease. These results support previous findings; however, the same study also found that participants who increased their consumption over time saw their risk of mild cognitive impairment increase significantly. This association between coffee consumption variation and risk of mild cognitive impairment attracted coverage from a variety of angles over a long period. Highlights include Washington Post, Netdoctor, Medical News Today, Tiscali, and Nachrichten.

Coffee consumption and its protective effect against Alzheimer’s Disease

A study published in the Journal of Neurology, Neurosurgery & Psychiatry found that coffee as well as alcoholic beverages, cholesterol lowering statins, and anti-inflammatory drugs like ibuprofen helped reduce the risk of Alzheimer’s Disease. The incidence of the disease maintains high levels of media interest throughout the year, and this research generated coverage in titles including The Guardian, Washington Post, Daily Mail, Yahoo! News, Western Morning News, Medical Xpress, Sprint News and Notizie Tiscali.

More on coffee consumption and Alzheimer ’s disease can be found here

Coffee consumption and health benefits

Coffee is the most popular drink worldwide after water, with over 400 billion cups being consumed each year. Due to this popularity the relationship between coffee consumption and various health benefits regularly attracts widespread coverage. This quarter, coverage highlights included Huffington Post, Elle, Business Insider, Yahoo, Etlehti, Elonce, El Gourmet Urbano, Eco Di Bergamo, Atlantico and Avisen.

Coffee consumption and fluid balance

There is still a broad misconception that coffee and caffeine are diuretics. This was reflected this quarter as rising heat in the summer months prompted a wealth of article advising citizens to avoid drinking caffeinated beverages under risk of dehydration. For example, the Hungarian National Office of Public Health has advised people to avoid coffee, alcohol, high caffeine and sugar soft drinks, as well as the consumption of fatty foods in anticipation of a heat wave. Media coverage includes titles such as Gizmodo, Noodls, Female First, Which, Hajdu, Promenad, Nordjyske, Netriport and MNO.

Please click here to find out more about coffee consumption and fluid balance.

Coffee consumption and its protective effect against type 2 diabetes

New research published in the European Journal of Clinical Nutrition found that people who drank coffee were approximately 50 percent less likely to develop type 2 diabetes compared to people who did not drink coffee. Following the publication of this study, coverage of the protective effect of coffee consumption against the risk of developing diabetes included top tier outlets including Huffington Post, Fox News, NeuroTalk, CHealth, Telegraf Online, Ziuanews, Sapo lifestyle, Msn, Yahoo and Canarias7.

Our dedicated topic on coffee consumption and type 2 diabetes can be found here


In Q4 we will be adding content about Coffee and type 2 diabetes, and publish the results of the consumer research we conducted across Europe to identify consumer awareness of diet and lifestyle messages related to type 2 diabetes risk reduction.

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ISIC the Institute for Scientific Research on Coffee 2015 ©

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