13th Edition – April 2015

Welcome to the latest edition of the Coffee & Health quarterly news bulletin. Below you will find information on the latest published research, topic updates and new information resources.

We aim to make the Coffee & Health website an interesting and useful resource for your everyday practice, work or research. As a subscriber to this news bulletin, you are also eligible to receive news alerts from Coffee & Health, which are distributed 1-2 times a month. If you wish to opt in to receiving these, please click here.

Please feel free to forward the news bulletin to colleagues – they can click here to sign up themselves!

EXPERT COMMENT: Dr Astrid Nehlig

Coffee remains one of the most researched components in the diet, and when taken overall, the evidence indicates that moderate caffeinated coffee consumption, namely 3-5 regular sized cups per day, is associated with a range of desirable physiological effects.

Dr Astrid Nehlig, a research director from the French National Medical Research Institute (INSERM) who’s main research interest lies in the effects of coffee and caffeine on health, explores some of the latest scientific research in this area. Click here to read more.


In January, the European Food Safety Authority published its anticipated draft scientific opinion on the use of health claims relating to caffeine. Based on the available body of scientific research, it was concluded that daily intake of caffeine up to 400mg does not raise safety concerns for adults. ISIC welcomed this opinion, and you can read our response here.

More information on caffeine and health can be found here on our website.


The latest addition to the redesigned Coffee & Health website is the Coffee and Bone Health topic. Commonly discussed in the media, the new topic will explore the potential impact of coffee consumption on bone mineral density and bone mechanical strength. Click here to find out more.

To accompany the launch of this topic, we worked with experts in the field of bone health and nutrition to develop a podcast and Q&A, which provide an easy-to-read overview of the science behind coffee consumption and bone health. To listen to the podcast, click here and to read the expert Q&A click here.


We regularly publish abstracts of the latest research papers on coffee and health, so you can see at a glance what's new in this area. If you haven’t had the chance to catch up with the latest research, you can find these on the Coffee & Health website. You can now also view these abstracts by topic, as well as by date.

Recent studies published include:

Coffee consumption and Melanoma Risk
This large US cohort study of over 400,000 participants looked to establish an association between the compounds in coffee and melanoma. Higher intake (over 400mg) of caffeinated coffee was found to be associated with a reduced risk of malignant melanoma.

E Lotfield et al, 2015, Coffee Drinking and Cutaneous Melanoma Risk in the NIH-AARP Diet and Health Study, Journal of the National Cancer Institute, published online ahead of print.

For more information on coffee and cancer, please click here

Coffee consumption during pregnancy and obesity in offspring
Previous research has found a link between the consumption of caffeine during pregnancy and increased likelihood of obesity. This study aimed to investigate this association further, and did not support an increased risk in childhood obesity in line with increased maternal caffeine consumption during pregnancy.

M A Klebanoff and S A Keim, 2015, Maternal serum paraxanthine during pregnancy and offspring body mass index at ages 4 and 7 years, Epidemiology, Volume 26 (2): 185-191, online ahead of print.

For more information on coffee and pregnancy, please click here

Caffeinated and decaffeinated coffee consumption, and risk of breast cancer
This study investigated the association between coffee and tea intake and breast cancer risk in over 300,000 women. The findings suggested that both caffeinated and decaffeinated coffee consumption are not associated with pre-menopausal breast cancer, and that caffeinated coffee may be associated with a reduced risk of post-menopausal breast cancer.

N Bhoo-Pathy et al, 2015, Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study, Breast Cancer Research, Volume 17, published online ahead of print.

For more information on coffee and cancer, please click here

Coffee consumption and potential benefits for postural stability in hemiparetic stroke patients
Evidence from this research suggests that caffeine intake may improve the balance control of hemiparetic stroke patients through postural stability.

W S Kim et al, 2014, Usual dose of caffeine has a positive effect on somatosensory related postural stability in hemiparetic stroke patients, Annals of Rehabilitation Medicine, published online ahead of print.

For more information on coffee and stroke, please click here

Coffee consumption and association with endometrial cancer risk
A large prospective study of over 560,000 British women was used to investigate the association between tea and coffee consumption and endometrial cancer risk. No significant association was found between tea consumption and endometrial cancer risk, and only a weak association was found with coffee consumption.

T O Yang et al, 2015, Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis, American Journal of Clinical Nutrition, Volume 101.

For more information on coffee and cancer, please click here

Association of coffee consumption with total and cause-specific mortality
A population-based cohort study of over 90,000 Japanese adults has suggested that coffee consumption is inversely (i.e. positively) associated with total mortality, and a lower risk of mortality from the three leading causes of death in Japan - heart disease, cerebrovascular disease and respiratory disease.

E Saito et al, 2015. Association of Coffee Intake with Total and Cause-specific Mortality in a Japanese population: the Japan Public Health Center-based Prospective Study, American Journal of Clinical Nutrition, published online ahead of print.

To find out more about coffee and cardiovascular health, click here

Caffeine consumption and risk of spontaneous abortion
Previous research has suggested that caffeinated beverages should be seen as a risk factor for spontaneous abortion. This prospective cohort study, involving Danish women planning pregnancy, reveals that caffeine consumption during early pregnancy was associated with a small, non-linear increase in spontaneous abortion.

K A Hahn et al, 2015. Caffeine and Caffeinated Beverage Consumption and Risk of Spontaneous Abortion, Human Reproduction, published online ahead of print.

To read more about caffeine and pregnancy, click here


Coffee is always a popular topic of interest in the media. We’ve collated media highlights from the last quarter which feature coffee research. In many cases, these stories reference a single new study or review. Where available, please follow the links to relevant sections on the Coffee & Health website.

Caffeine and health claims
Following the publication of EFSA’s draft scientific opinion on the safety of caffeine, we have seen notable media conversation around caffeine, health and proposed regulations. The opinion itself was reported in trade publications across Europe, including Beverage Daily,  Dagens Medicin (Sweden) and Repubblica (Italy).

More information on caffeine and health can be found on our website

Drinking Coffee may lower the risk of liver cancer
A new report published by World Cancer Research Fund International, in partnership with the American Institute for Cancer Research, has provided an in-depth review of existing global research linking diet, physical activity and weight to the risk of developing liver cancer. Strong evidence was found to suggest coffee consumption may reduce the risk of liver cancer; with just one cup found to reduce risk by 14%. Much of the initial media coverage focused on the damaging effects of alcohol with a brief reference to the protective effects of coffee, for example The Guardian, The Daily Mirror and The Daily Telegraph, however a later round of coverage chose to focus on the positive benefits of coffee consumption: Medical Daily, Mail Online, Health.com and EmaxHealth

To read ISIC’s opinion on this report click here, and to find out more about coffee consumption and liver function click here

Drinking coffee reduces clogged arteries risk
Drinking three to five cups of coffee a day could be associated with reduced occurrence of atherosclerosis, a new cross-sectional study has suggested. Over 25,000 Korean men and women took part in regular heart screenings and completed food questionnaires. Other risk factors such as smoking and levels of physical activity were also taken into consideration. Researchers found that those who consumed regular, moderate amounts of coffee had the lowest prevalence of visible calcium deposits in their arteries, adding to the existing body of research which suggests an inverse association between coffee consumption and cardiovascular disease. The findings of this study attracted huge international media interest, with coverage appearing in titles including BBC News, TIME, Huffington Post, LiveScience, ELLE.com and NetDoctor.

To find out more about coffee consumption and CVD, click here

Four cups of coffee a day may be associated with a lower risk of melanoma
Research published in the Journal of the National Cancer Institute surveyed the coffee habits of over 447,000 people, with an average follow up period of 10 years. The findings revealed that coffee consumption was inversely associated with risk of malignant melanoma; with those who drank four or more cups of coffee a day up to 20% less likely to develop melanoma. Decaffeinated coffee was found to have no effect on the risk levels. Widespread coverage was observed internationally, with highlights including Daily Mail, Medical Xpress, Live Science, Today Health (video), Medical News Today, Prevention.com, Washington Post, BeverageDaily, Tv2, Paradisi, Yahoo Lifestyle and Kurier

To read the study’s abstract, click here, and to find out more about coffee and cancer, click here

Can coffee reduce your risk of MS?
New research which reviewed two separate studies from Sweden and the U.S. has suggested coffee consumption may be associated with a reduced risk of developing multiple sclerosis. A total of 3,000 healthy people and 2,700 people suffering with MS were studied, with non-coffee drinkers found to be 1.5 times more likely to develop MS than those who consumed four or more cups of coffee daily. The study findings were covered widely by science and health media, with many articles referencing previous research which has suggested an association between coffee and caffeine consumption and reduced risk of neurological disorders. Coverage highlights included Mail Online, Medical News Today, Examiner.com, Fox News and Medical Xpress. The full study is set to be presented at the American Academy of Neurology's 67th Annual Meeting in April.

For more information on the relationship between coffee, caffeine and neurological disorders click here

Coffee linked to reduced endometrial cancer risk
A study conducted by Imperial College London investigated how dietary factors affect the risk of endometrial cancer. Using data from 1,300 women, the researchers were able to determine that drinking three cups of coffee a day reduced endometrial cancer risk by 19%, compared with women who drank less than one cup per day. The findings of this study were covered across Europe, by outlets including MedicalXpress, Medical Daily, Cosmopolitan, Expressen.se, Pourquoi Docteur and LaNutrition.fr


We will continue to upload new content to the Coffee & Health website to ensure materials are fresh and up-to-date. In the second quarter of 2015, we will be working with experts to produce a vodcast on coffee, aroma and its physiological effects to further enhance the popular All about Coffee section

In May, ISIC will also be hosting a symposium at EuroPRevent 2015 in which leading researchers will discuss the latest scientific evidence regarding coffee consumption and CVD mortality risk. Keep any eye on the website for the resulting content.


To view and share the latest research and news on coffee, caffeine and health, join us on Twitter! Our Twitter name is @coffeeandhealth, to follow us click here.

If you have not already signed up to receive the news bulletin by email, stay up-to-date with all the latest news on Coffee & Health, by clicking here.

If you would like to unsubcribe to this email click here