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Coffee & Health quarterly news bulletin

19th Edition - 2016

Welcome to the latest edition of the
Coffee & Health quarterly news bulletin.

In this issue you will find spotlights on specific subject areas: Mental performance, Sports performance, and Cardiovascular disease. These cover the latest science, media articles and ISIC activity as appropriate. You can also stay up-to-date with additional scientific papers from Q3 by reading ‘The Latest Research on Coffee and Health’ section.

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EXPERT COMMENT – Dr Renata Riha, Consultant in Sleep and Respiratory Medicine at the Royal Infirmary, Edinburgh

In this expert comment, Dr Renata Riha examines the relationship between coffee, sleep, and alertness, providing comment on ISIC’s recent coffee and sleep expert roundtable, and insight on how to get a good night’s sleep.



Coffee and sleep

This quarter, ISIC fully reviewed the “Mental performance” topic on the Coffee & Heath website and incorporated a brand new sub-topic, “caffeine and sleep”.

In July, ISIC published an expert report examining the relationship between coffee, sleep, and alertness , featuring input from independent European specialists. An accompanying infographic was designed to outline the research discussed.

Focusing on sleep quality during the warm summer months when many people complain of sleepless nights, coffee and sleep was a popular topic in the media. Coverage included: Daily Express, Novinky, Daily Mail, Lineamarco and MX.

Two new research papers on caffeine and sleep were published this quarter:

N S Chaudhary et al. used data extracted from the 2007–2008 National Health and Nutritional Examination Survey to determine whether caffeine consumption was associated with insomnia symptoms from a population perspective, and whether this relationship depended on habitual sleep duration. The conclusion suggests that the association between caffeine use and insomnia symptoms depends on habitual sleep duration at a population level.
N S Chaudhary et al, 2016. Caffeine consumption, insomnia, and sleep duration: Results from a nationally representative sample. Nutrition, published online ahead of print.

A systematic review by E Bertazzo-Silviera et al. sought to answer the question “In adults, is there any association between sleep bruxism (nocturnal tooth grinding) and alcohol, caffeine, tobacco, or drug abuse?” From among 818 studies, the authors selected 7 for inclusion, in which samples ranged from 51 to 10,229 participants. The review found that on the basis of limited evidence, sleep bruxism was associated positively with alcohol, caffeine, and tobacco. The association between the studied drugs could not be discredited; however, the researchers suggest there is still a need for stronger evidence from studies with greater methodological rigor.
E Bertazzo-Silviera et al, 2016. Association between sleep bruxism and alcohol, caffeine, tobacco, and drug abuse. Journal of the American Dental Association, published online ahead of print.

World Alzheimer’s Day

In support of World Alzheimer’s Day on 21st September, ISIC reviewed the scientific evidence surrounding coffee consumption and its potential to reduce the risk of Alzheimer’s Disease, and published the third edition of its report The good things in life: can coffee consumption reduce the risk of developing Alzheimer’s Disease? The newly-updated report provides a comprehensive overview of the latest research into coffee, caffeine and Alzheimer’s Disease.

World Alzheimer’s Day was a topic of interest in the media and coverage of the report included: Affaritaliani, Brief Report, Voglia di Salute, Green Planner, Di Lei, The Express, Il Tempo, AGR, Zazoom, Italia a Tavola, Meteo Web, Kvedomosti and The Sun.

Research on coffee and neurodegenerative disorders this quarter included an observational cohort study by M Moccia et al. which investigated motor and non-motor correlates of caffeine consumption in newly diagnosed Parkinson’s disease (PD). 79 newly diagnosed, drug naïve PD patients were followed up for 4 years, and caffeine consumption was found to be associated with a reduced accrual of motor and non-motor disability.
M Moccia et al, 2016. Caffeine Consumption and the 4-Year Progression of de Novo Parkinson’s disease. Parkinsonism and Related Disorders, published online ahead of print.


Thanks to the excitement of the Olympic and Paralympic Games in Rio this summer, sports performance was high on the media and public agenda. ISIC published a new blog post on the website and reissued an expert roundtable report on the role of coffee and caffeine in sports performance, highlighting the latest research and proposed mechanisms.

ISIC worked with UK national newspaper The Times to provide a comment from former Olympian and roundtable chairman, Greg Whyte, who contributed to an article on how coffee consumption is becoming a popular way to enhance performance among professional and amateur athletes alike.

Given the topicality of the subject, coffee and sports performance was covered widely in the press this quarter: ITV, Aktiv Traning, Indisa, Taringa, Health Care Eng and Parlamentni Listy.


On World Heart Day (29th September), ISIC published updated scientific evidence surrounding coffee consumption and its potential to reduce the risk of cardiovascular disease.

The latest facts and scientific research on coffee and cardiovascular disease can be found in the newly-updated “Cardiovascular health” topic section of the website. ISIC also published the second edition of its report The good things in life: can coffee protect against the risk of CVD mortality?, which provides a comprehensive overview of the latest research into coffee, caffeine and cardiovascular disease.

The report was covered in the media by: MSN, The Daily Meal, Beverage Daily, Nutra Ingredients, Wales Online, Mirror, Irish Mirror, Express, and News Grio.

Research on coffee and cardiovascular health this quarter included a prospective cohort study by G Grosso et al. of 28561 individuals followed for 6.1 years. Researchers tested the association between coffee consumption and risk of all-cause, cardiovascular disease and cancer death and found that coffee consumption was associated with decreased risk of mortality. The protective effect was even stronger when stratification by smoking status and alcohol intake was performed.
G Grosso et al, 2016. Coffee consumption and mortality in three Eastern European countries: results from the HAPIEE (Health, Alcohol and Psychological factors in Eastern Europe) study. Public Health Nutrition, published online ahead of print.


We regularly publish abstracts of the latest research papers on coffee and health, so you can see at a glance what's new in this area. If you haven’t had the chance to catch up with the latest research, you can find abstracts here. You can view these abstracts by topic, as well as by date.

Studies this quarter on coffee and cancer included:

Coffee and non-melanoma skin cancer

A literature review and meta-analysis of observational studies by S Caini et al. investigated the association between coffee and tea intake and non-melanoma skin cancer risk. Findings suggest that coffee intake exerts a moderate protective effect against basal cell cancer development, probably through the biological effect of caffeine; however the authors suggest reviewing these results with caution and that they should be verified in randomised clinical trials.

S Caini et al, 2016. Coffee, Tea and Caffeine Intake and Risk of Non-melanoma skin cancer: A Review of the Literature and Meta-Analysis. European Journal of Nutrition, published online ahead of print.

Find further information on coffee and skin cancer.

Coffee consumption and gastric cancer

Y Xie et al. conducted a systematic analysis of relevant population studies to derive a more precise estimation of the association between coffee consumption and gastric cancer. The meta-analysis indicated that an increase in coffee consumption, up to 4 cups per day, might be associated with a decreased risk of gastric cancer.

Y Xie et al, 2016. Coffee consumption and risk of gastric cancer: an updated meta-analysis. Asia Pacific Journal of Clinical Nutrition, Volume 25 (3).

Read more on coffee and cancer of the digestive tract.

Coffee and hepatocellular carcinoma

A meta-analysis of 11 relevant studies performed by K Bai et al. considered the growing evidence that coffee consumption is inversely i.e. favourably associated with a reduced risk of hepatocellular carcinoma. The findings confirmed the suggested association, detecting the protective effect among a healthy population and patients with chronic liver diseases, suggesting that coffee consumption may also prevent the development of liver cirrhosis.

K Bai et al, 2016. Coffee Consumption and Risk of Hepatocellular Carcinoma: A Meta-Analysis of Eleven Epidemiological Studies. Onco Targets and Therapy, Volume 9.

Find out more on coffee and liver cancer.

Coffee and prostate cancer

S F Peisch et al. conducted a review and summary of evidence on the role of diet and lifestyle factors and prostate cancer progression, with a specific focus on habits after diagnosis and the risk of subsequent disease recurrence, progression, or death. The study found that a variety of dietary and lifestyle factors appear to affect prostate cancer progression. In particular, exercise and smoking cessation may reduce the risk of prostate cancer progression and death, although further investigation is required.

S F Peisch et al, 2016. Prostate cancer progression and mortality: a review of diet and lifestyle factors. World Journal of Urology, published online ahead of print.

Read more on coffee and prostate cancer.

Coffee and brain tumours

A cohort study by T Ogawa et al. in a Japanese population evaluated the association between coffee and green tea intake, and brain tumour risk. Results suggest that coffee consumption may reduce the risk of brain tumour, including that of glioma, a malignant tumour of the glial tissue of the nervous system.

T Ogawa et al, 2016. Coffee and Green Tea Consumption in Relation to Brain Tumour Risk in a Japanese Population. International Journal of Cancer, published online ahead of print.

Find further information on coffee and brain tumours.

Further studies to note from this quarter include:

Coffee and premenstrual syndrome

A C Purdue-Smithe et al. evaluated the association between total caffeine, coffee, and tea intake and the development of PMS in a case-control study nested within the prospective Nurses’ Health Study II. Findings suggest that caffeine intake is not associated with PMS, and that current recommendations for women to reduce caffeine intake may not help prevent the development of PMS.

A C Purdue-Smithe et al, 2016. A prospective study of caffeine and coffee intake and premenstrual syndrome. American Journal of Clinical Nutrition, published online ahead of print.

Read more about coffee and your health.

Coffee consumption and pregnancy

M C Tollanes et al. investigated the association between caffeine intake by pregnant women and risk of cerebral palsy (CP) in vulnerable low-birth-weight neonates. The study was based on The Norwegian Mother and Child Cohort Study, comprising more than 100,000 live-born children, of whom 222 were subsequently diagnosed with CP. Results suggested maternal total daily caffeine consumption before and during pregnancy was not associated with CP risk in children, but that an increased risk observed with caffeinated soft drinks warrants further investigation.

M C Tollanes et al, 2016. Intake of Caffeinated Soft Drinks Before and During Pregnancy, But not Total Caffeine Intake, is Associated with Increased Cerebral Palsy Risk in the Norwegian Mother and Child Cohort Study. The Journal of Nutrition, published online ahead of print.

Read more on coffee and pregnancy.


In Q4 2016, ISIC will focus its activity on coffee, cognition and ageing.

From 5th–7th October, ISIC attended the European Union Geriatric Medicine Society’s 2016 congress and hosted a symposium on ‘Nutrition, Coffee and Age-Related Cognitive Decline’. Expert speakers discussed the research surrounding the role of coffee and caffeine in limiting age-related cognitive decline, the potential mechanisms involved, and a preventative approach for patients. ISIC will publish a post-symposium report shortly.

Further content to be published in Q4 includes:

  • A full topic update on coffee and type 2 diabetes
  • An updated coffee and diabetes consumer awareness infographic
  • A practitioner Q&A on coffee and age-related cognitive decline
  • Insights into how the social aspects of coffee drinking might affect cognitive function and wellbeing in older adults

For further updates, opt in to receive ISIC news alerts

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ISIC the Institute for Scientific Research on Coffee 2016 ©

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