What effect does coffee have on the inflammatory markers associated with type 2 diabetes?

A correlation has been observed between subclinical inflammation, a low level of inflammation, and glycaemic control in patients with type 2 diabetes mellitus, which suggests that such inflammation may play a role in the progress of diabetes. Serum amyloid A is a type of lipoprotein that may be associated with chronic inflammation in the body.

  • A Finnish study tested the effects of progressively increasing coffee consumption in obese volunteers in a medium term intervention trial (in the first month, participants abstained from coffee, for the second month 4 cups of coffee were consumed per day and in the third month, participants had 8 cups per day). No effects in the OGTT were seen. Coffee consumption appeared to have beneficial effects on some markers of subclinical inflammation, considered to be risk factors for type 2 diabetes13.
  • And a Greek study, which controlled for oxidative stress and inflammatory biomarkers, suggested that the inverse association between habitual coffee drinking and diabetes was found to be mediated by serum amyloid A levels14.

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