1. International Diabetes Federation, ‘About Diabetes’. Available at:
  2. Van Dam R.M. et al. (2002): Coffee consumption and risk of type 2 diabetes mellitus. Lancet,360:1477-1478.
  3. Huxley R. et al. (2009):Coffee, Decaffeinated Coffee, and Tea Consumption in Relation to Incident Type2 Diabetes Mellitus. Arch Int Med, 169:2053-2063.
  4. Carlstrom M. and Larsson S.C.(2018): Coffee consumption and reduced risk of developing type 2 diabetes: asystematic review with meta-analysis. Nutr Revs,76(6):395-417
  5. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2015): Scientific Opinion on the     safety of caffeine. EFSA Journal, 13(5):4102
  6. Jiang X. et al. (2014): Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies. EJCN, 53(1):25-38.
  7. Ding M. et al. (2014): Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: A systematic review and dose response meta-analysis. Diab Care, 37(2):569-586.
  8. Bhupathiraju S.N. et al.(2013): Caffeinated and caffeine free beverages and risk of type 2 diabetes. AJCN, 97(1):155-166.
  9. Osama H. et al (2021) Coffee and Type 2 Diabetes risk: Is the Association Mediated by Adiponectin, Leptin, C-reactive protein, or Interlukin-6? A systematic review and meta-analysis. Int J Clin Pract, 75(6): e13983.
  10. van Dijk A.E. et al. (2009): Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diab Care, 32:1023-1025.
  11. Tajik N. et al. (2017): The potential effects of chlorogenic acid, the main phenolic compounds in     coffee, on health: a comprehensive review of the literature. Eur J Nutr,7:2215-2244.
  12. Wierzejska R. (2020): Coffee in the diet and prevention of diabetes. Clin Diabetol, 9(2):144-148.
  13. Kempf K. et al. (2010): Effects of coffee consumption on subclinical inflammation and other risk     factors for type 2 diabetes: a clinical trial. AJCN, 91:950-957.
  14. Koloverou E. et al.     (2015): The evaluation of inflammatory and oxidative stress biomarkers on     coffee-diabetes association: results from the 10 year follow up of the ATTICA Study (2002-2012). EJCN, 69(11):1220-1225.
  15. International Diabetes Federation. IDF Diabetes Atlas, 10th edn. Brussels, Belgium: International Diabetes Federation, 2021. Available at:
  16. Zhang Y. et al. (2011): Coffee consumption and the incidence of type 2 diabetes in men and women     with normal glucose tolerance: The Strong Heart Study. Nutr, Metab & Cardio Dis, 21(6):418-423.
  17. van Dieren S. et al. (2009): Coffee and tea consumption and risk of type 2 diabetes. Diabetologia,     52:2561-2569.
  18. Oba S. et al. (2010): Consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in Japanese men and women. BJN, 103:453-459.
  19. Sartorelli D.S. et al. (2010): Differential effects of coffee on the risk of type 2 diabetes  according to meal consumption in a French cohort of women: the E3N/EPIC cohort study. AJCN, 91:1002-1012.
  20. Boggs D.A. et al. (2010): Coffee, tea, and alcohol intake in relation to risk of type 2 diabetes in African American women. AJCN, 92:960-966.
  21. Doo T. et al. (2014): Coffee intake and risk of type 2 diabetes: the multi-ethnic cohort. Pub Health Nutr, 17(6):1328–1336.
  22. Hjellvik V. et al. (2011): Boiled coffee intake and subsequent risk for type 2 diabetes. Epidemiol, 22(3):418-421.
  23. Lin W.Y. et al. (2011): Coffee consumption is inversely associated with type-2 diabetes in China. Eur J Clin Invest, 41(6):659-66F6.
  24. Natella F. and Scaccini C. (2012): Role of coffee in modulation of diabetes risk. Nutr Revs, 70(4):207-217.
  25. Muley A. et al. (2012): Coffee to reduce risk of type-2 diabetes?: a systematic review. Curr Diab Revs, 8:162-168.
  26. Santos R.M. (2016): Coffee consumption, obesity and type 2 diabetes: a mini review. Eur J Nutr, 55(4):1345-1358.
  27. Bhupathiraju S.N. et al. (2014): Changes in coffee intake and subsequent risk of type 2 diabetes: three large cohorts of US men and women. Diabetalogia, 57(7):1346-1354.
  28. Lee J.H. et al. (2016): Effect of coffee consumption on the progression of type 2 diabetes mellitus among prediabetic individuals. Korean J Fam Med, 37(1):7–13.
  29. Mirmiran P. et al. (2018): Long-term effects of coffee and caffeine intake on the risk of pre-diabetes and type 2 diabetes: Findings from a population with low coffee consumption. Nutr Metab Cardiovasc Dis,28(12):1261-1266.
  30. Bae J.M. (2021) Coffee consumption and risk of type 2 diabetes mellitus in Asians: A meta-epidemiological study of population-based cohort studies. World J Diab, 12(6):908-915.
  31. Du Y. et al. (2007): Association of serum caffeine concentrations with serum glucose levels in caffeine-drug users and non-users – results of German National Health Surveys. Diab, Obes Metab, 9:756-758.
  32. Shi X. et al. (2016): Acute caffeine ingestion reduced insulin sensitivity in healthy subjects: a systematic review and meta-analysis. Nutr J, 15(1):103.
  33. Robinson L.E. et al. (2009): Acute caffeine ingestion and glucose tolerance in women with or without gestational diabetes mellitus. J Obs Gynae Canada, 31:304-312.
  34. Lee A.H. et al. (2016): Plasma concentrations of coffee polyphenols and plasma biomarkers of     diabetes risk in healthy Japanese women. Nutr Diab, 6:e212.
  35. Cao H. et al. (2018): Dietary polyphenols and type 2 diabetes: Human study and clinical trials. Crit Rev Food Sci Nutr, 11:1-19.
  36. Bassoli B.K. et al. (2008): Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia. Cell Biochem Funct; 26: 320–3.
  37. Gao F. et (2018): Coffee consumption is positively related to insulin secretion in the Shanghai High-Risk Diabetic Screen (SHiDS) Study. Nutr & Metab 15:84.
  38. Naveed M. et al. (2018): Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomed Pharmacother, 97:67-74.
  39. Williamson G. (2020): Protection against developing type 2 diabetes by coffee consumption: assessment of the role of chlorogenic acid and metabolites on glycaemic responses. Food func, published online ahead of print.
  40. Huang D. et al (2020) Metabolomic signatures of long-term coffee consumption and risk of Type 2 diabetes in women. Diab Care, 43(10):2588-2596.
  41. Mattila P. et al. (2006): Phenolic acids in berries, fruits, and beverages. J Agric Fd Chem,54:7193-7199.
  42. Psaltopoulou T. et al. (2010): The role of diet and lifestyle in primary, secondary, and tertiary diabetes prevention: a review of meta-analyses. Rev Diabetic Studies, 7:26-35.
  43. Kwok M.K. (2016): Habitual coffee consumption and risk of type 2 diabetes, ischemic heart disease depression and Alzheimer’s disease: a Mendelian randomization study. Sci Rep,6:36500.
  44. Kim A.N. (2020) Coffee consumption, genetic polymorphisms, and risk of type 2 diabetes mellitus: a pooled analysis of four prospective cohort studies. Int J Environ Res & Pub Health, 17(15):5379.
  45. Yamaji T. et al. (2004): Coffee consumption and glucose tolerance status in middle-aged Japanese     men. Diabetologia, 47:2145-2151.
  46. Loopstra-Masters R.C. et al. (2011): Associations between the intake of caffeinated and decaffeinated coffee and measures of insulin sensitivity and beta cell function. Diabetologia, 54(3):320-328.
  47. Alperet D.J. et al. (2020): The effect of coffee consumption on insulin sensitivity and other biological risk factors for type 2 diabetes: a randomized placebo-controlled trial. Am J Clin Nutr, 111(2):448-458.
  48. Neves J.S. et al. (2018): Caffeine consumption and mortality in diabetes: An analysis of NHANES 1999-2010. Front Endocrinol, 9:547.
  49. Wedick N.M. et al. (2011): Effects of caffeinated and decaffeinated coffee on biological risk factors     for type 2 diabetes: a randomized controlled trial. Nutr J, 10:93.
  50. Hiramatsu T. et al. (2012): Coffee consumption and serum-γ-glutamyltransferase, and glucose tolerance status in middle-aged Japanese men. Clin Chem Lab Med, 25:1-7.
  51. Kato M. et al. (2009): Psychological factors, coffee and risk of diabetes mellitus among middle-aged Japanese: a population-based prospective study in the JPHC study cohort. Endocr J, 56(3):459-468.
  52. Omagari K. et al. (2014): Coffee consumption is inversely associated with depressive symptoms in Japanese patients with type 2 diabetes. J Clin Biochem Nutr, 55(2):135-142.
  53. Goto A. et al. (2011): Coffee and Caffeine Consumption in Relation to Sex Hormone-Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women. Diab, 60:269-275.

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