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Coffee & Health

Coffee intake and oral-oesophageal cancer: follow-up of 389,624 Norwegian men and women 40 – 45 years

A Tverdal et al, (2011)
British Journal of Cancer, published online ahead of print
June 6, 2011


The evidence on the relationship between coffee intake and cancer of the oral cavity and oesophagus is conflicting and few follow-up studies have been done.


A total of 389,624 men and women 40–45 years who participated in a national survey programme were followed with respect to cancer for an average of 14.4 years by linkage to the Cancer Registry of Norway. Coffee consumption at baseline was reported as a categorical variable (0 or o1 cup, 1–4, 5–8, 9+ cups per day).


Altogether 450 squamous oral or oesophageal cancers were registered during follow-up. The adjusted hazard ratios with 1–4 cups per day as reference were 1.01 (95% confidence interval: 0.70, 1.47), 1.16 (0.93, 1.45) and 0.96 (0.71, 1.14) for 0 or o1 cup, 5–8 and 9+ cups per day, respectively. Stratification by sex, type of coffee, smoking status and dividing the end point into oral and oesophageal cancers gave heterogeneous and non-significant estimates.


This study does not support an inverse relationship between coffee intake and incidence of cancer in the mouth or oesophagus, but cannot exclude a weak inverse relationship.

British Journal of Cancer advance online publication, 31 May 2011; doi:10.1038/bjc.2011.192

© 2011 Cancer Research UK

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