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Coffee & Health
Type 2 diabetes

Coffee consumption and risk of metabolic syndrome: a meta-analysis

F Shang et al, 2015
Diabetes and Metabolism, published online ahead of print
October 5, 2015



The association between coffee consumption and risk of the metabolic syndrome (MetS) remains controversial. For this reason, a meta-analysis including dose–response analysis was conducted to quantitatively summarize the association between coffee intakes and MetS risk.


A search was made of PubMed and the China National Knowledge Infrastructure (CNKI) for relevant articles published between 1 January 1999 and 31 May 2015. All observational studies related to the relationship of coffee consumption and risk of MetS were included in the meta-analysis. The result was estimated by a random-effects model, while the dose–response relationship was assessed by a restricted cubic spline model.


Eleven published reports including 13 studies with a total of 159,805 participants were eligible for our meta-analysis. The aggregated result (and 95% CI) for the highest vs lowest category of coffee consumption was 0.872 (0.781–0.975). After excluding one study with a relative risk (RR) < 0.300, the aggregated result (and 95% CI) was 0.889 (0.801–0.986). A non-linear relationship was found between coffee consumption and the MetS in the dose–response analysis.


This meta-analysis suggests that coffee consumption is associated with a low risk of MetS, and further studies to address the question of causality are now needed.

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