The aim of this crossover study was to investigate the acute effects of caffeinated and decaffeinated coffee consumption on appetite feelings, energy intake, and appetite-, inflammation-, stress-, and glucose-metabolism related markers. Sixteen healthy men, aged between 21 – 39 years, with a BMI range of 19.7-28.6 kg/m received in a random order on 3 separate occasions a standard breakfast snack with 200mL of either caffeinated coffee (3mg/kg/bw), decaffeinated coffee, or water (control). Before intervention and at standard time points following breakfast consumption, participants recorded their appetite feelings and blood samples were collected for measurement of circulating glucose, insulin, cortisol, and appetite- and inflammation- related markers. At 180 minutes, participants consumed a meal ad libitum. The appetite -related ratings, the appetite plasma hormonal responses as well as the plasma glucose, serum insulin, and plasma and serum inflammatory marker responses did not show an overall intervention effect or a time X intervention interaction. Ad libitum energy intake did not differ among the 3 interventions. A significant intervention effect and a time x intervention interaction were found for serum cortisol;  cortisol concentrations were significantly higher following the caffeinated coffee intervention, compared to control, at 60 min and thereafter. ‘In conclusion, the usually consumed amount of caffeinated coffee does not have short-term effects on appetite, energy intake, glucose metabolism, and inflammatory markers, but it increases circulating cortisol concentrations in healthy men’.