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Coffee & Health
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Cardiovascular health
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Affects of coffee consumption
  1. Mostofsky E, et al. (2012). Habitual coffee consumption and risk of heart failure: a     dose-response meta-analysis. Circ Heart Fail. 5(4):401-5.
  2. Malerba S, et al. (2013): A meta-analysis of prospective studies of coffee consumption and mortality for all causes, cancers and cardiovascular diseases. Eur J Epidemiol, 28(7):527-39.
  3. Liu J, et al. (2013). Association of Coffee Consumption with All-Cause and     Cardiovascular Disease Mortality. Mayo Clinic Proc. 88:10.
  4. Rebello SA & van Dam RM. (2013). Coffee Consumption and Cardiovascular     Health: Getting to the Heart of the Matter. Curr CardiolReps. 15:403.
  5. Ding M, et al (2014). Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies. Circ. 129(6):643-59.
  6. Crippa A, et al. (2014). Coffee consumption and mortality from all causes,     cardiovascular disease, and cancer: a dose-response meta-analysis. Am J Epidemiol, 180(8):763-75.
  7. Rodriguez Artalejo F & Lopez Garcia E. (2017). Coffee Consumption and Cardiovascular     Disease: A condensed review of epidemiological evidence and mechanisms, J Agric Fd Chem. 66(21):5257-63.
  8. O’Keefe JH, et al. (2018): Coffee for Cardioprotection and Longevity. Prog Cardiovasc Dis. 61(1):38-42.
  9. Voskoboinik A, et al. (2018): Cardiovascular effects of caffeinated beverages. Trends in Cardiovasc Med. S1050-1738(18)30177-4.
  10. Wu J, et al. (2009): Coffee consumption and the risk of coronary heart disease: a meta-analysis of 21 prospective cohort studies. Int J Cardiol. 137:216-25.
  11. Sugiyama K, et al. (2010). Coffee consumption and mortality due to all causes,     cardiovascular disease, and cancer in Japanese women. J Nur. 140(5):1007-13.
  12. de Koning Gans JM, et al. (2010). Tea and coffee consumption and cardiovascular morbidity and mortality. Arterioscler Thromb Vasc Biol. 30:1665-71.
  13. European Food Safety Authority (EFSA) Panel on Dietetic Products, Nutrition and Allergies (NDA). (2015). Scientific Opinion on the safety of caffeine. EFSA Journal. 13(5):4102.
  14. Ahmed HN, et al. (2009). Coffee consumption and risk of heart failure in men: an analysis from the cohort of Swedish men. Am Heart J. 158:667-72.
  15. Nilson LM, et al. (2009). Consumption of filtered and boiled coffee and the risk of first acute myocardial infarction: a nested case/referent study. Nutr Metabol & Cardiovasc Dis. 20(7):527-35.
  16. Larrson SC & Orsini N. (2011). Coffee consumption and risk of stroke: A dose-response meta-analysis of prospective studies. Am J Epidemiol. 174(9):993-1001.
  17. Kim B, et al. (2012). Coffee consumption and stroke risk: A meta-analysis of     epidemiologic studies. Korean J Fam Med. 33(6):356-65.
  18. Lopez-Garcia E.,et al. (2009). Coffee consumption and risk of stroke in women. Circ.     119:1116-23.
  19. Leurs LJ, et al. (2010): Total fluid and specific beverage intake and mortality due to ID and stroke in the Netherlands cohort study. Br J Nutr. 104:1212-21.
  20. Lutsey PL, et al. (2009): Dietary intake and the development of the metabolic     syndrome. The Atherosclerosis Risk in Communities Study. Am Heart J1. 57:1081
  21. Liebeskind DS, et al. (2015): The coffee paradox in stroke: increased consumption     linked to fewer strokes. Nutr Neurosci. 22:1476–8305.
  22. Kokubo Y, et al. (2013). The Impact of Green Tea and Coffee Consumption on the     Reduced Risk of Stroke Incidence in Japanese Population: The Japan Public Health Center-Based Study Cohort. Stroke. 44(5):1369-74.
  23. Deng C. (2018). Strokeand food groups: an overview of systematic reviews and meta-analyses. Pub Health Nutr. 21(4):766-76.
  24. Lee J, et al (2017). Relationship betweencoffee consumption and stroke risk in Korean population: the Health Examinees (HEXA) Study. Nutr J. 16(1):7.
  25. Cheng M, et al. (2014). Caffeine Intake and Atrial Fibrillation Incidence: Dose Response Meta-analysis of Prospective Cohort Studies. Can J Cardiol. 30(4):448-54.
  26. Caldeira D, et al. (2013): Caffeine does not increase the risk of atrial fibrillation: a systematic review and meta-analysis of observational studies. Heart. 99:1383-9.
  27. Mostofsky E, et al. (2015). Risk of Atrial Fibrilation Associated with Coffee Intake: Findings from the Danish Diet, Cancer, and Health Study. Eur J Prev Cardiol. 23(9):922-30.
  28. Larsson SC, et al. (2015). Coffee consumption is not associated with increased risk of atrial fibrillation: results from two prospective cohorts and a meta-analysis. BMC Medicine. 13(1):207.
  29. Conen D, et al. (2010). Caffeine consumption and incident atrial fibrillation in     women. AJCN. 92(3):509-14.
  30. Frost L & Vestergaard P. (2005). Caffeine and risk of atrial fibrillation or flutter: the Danish Diet, Cancer and Health Study. AJCN. 81:578-82.
  31. Casiglia E, et al. (2018). Caffeine intake reduces incident atrial fibrillation at a population level. Eur J Prev Cardiol. 25(10):1055-62.
  32. Abdelfattah R, et al. (2018). Does caffeine consumption increase the risk of new-onset     atrial fibrilation? Cardiology. 140(2):106-14.
  33. Geleijnse JM. (2008): Habitual coffee consumption and blood pressure: An     epidemiological perspective. Vasc Health Risk Man. 4(5):963-70.
  34. Mesas AE, et al. (2011). The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis. AJCN. 94(4):1113-26.
  35. Zhang Z, et al. (2011). Habitual coffee consumption and risk of hypertension: a     systematic review and meta-analysis of prospective observational studies. AJCN. 93(6):1212-9.
  36. Rhee JJ, et al. (2016). Coffee and Caffeine Consumption and the Risk of Hypertension in Postmenopausal Women. AJCN. 103(1):210-7.
  37. Renda G, et al. (2012). Genetic determinants of blood pressure responses to caffeine drinking. AJCN. 95(1):241-8.
  38. Grosso G, et al. (2017). Long-Term Coffee Consumption Is Associated with Decreased Incidence of New-Onset Hypertension: A Dose-Response Meta-Analysis. Nutr. 9(8):890.
  39. Navarro AM, et al. (2017): Coffee consumption and risk of hypertension in the SUN     Project. Clin Nutr. S0261-5614(17)31429-2.
  40. D’Elia L, et al. (2017): Coffee consumption and risk of hypertension: a dose-response meta-analysis of prospective studies. Eur J Nutr. doi: 10.1007/s00394-017-1591-z.
  41. Xie C, et al. (2018): Coffee consumption and risk of hypertension: a systematic review and dose-response meta-analysis of cohort studies. J Hum Hypertens. 32(2):83-93.
  42. Miranda AM, et al. (2018): The association between genetic risk score and blood     pressure is modified by coffee consumption: Gene-diet interaction analysis in a population-based study. Clin Nutr. S0261-5614(18)31246-9.
  43. Urgert R & Katan MB. (1996).The cholesterol-raising factor from coffee beans. J R Med. 89(11):618-23.
  44. Jee SH, et al. (2001). Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials. Am J Epidemiol. 153:353-62.
  45. Nystad T, et al. (2010). The effect of coffee consumption on serum total cholesterol in the Sami & Norwegian populations. Public Health Nutrition. 13(11):1818-25.
  46. Correa TAF, et al. (2013). Paper filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree. Nutrition. 29:977-81.
  47. Grioni S, et al. (2015): Espresso coffee consumption and risk of coronary heart disease in a large Italian cohort. PLoS One. 6;10(5):e0126550.
  48. Buscemi S, et al. (2010): Acute effects of coffee on endothelial function in  healthy subjects. Eur J Clin Nutr. 64(5):483-9.
  49. Buscemi S, et al. (2010). Coffee and endothelial function: a battle between caffeine and antioxidants. Eur J Clin Nutr. 64:1242-3.
  50. Aqudelo-Ochoa GM. (2016). Coffee consumption increases the antioxidant capacity of     plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled trial. J Nutr. 146(3):524-31.
  51. Refsum H, et al. (2006). The Hordaland Homocysteine Study: a community based study of homocysteine, its determinants, and associations with disease. J Nutr. 136 (6suppl):17731S-40S.
  52. Henkey GJ & Eikelboom JW. (1999). Homocysteine and Vascular Disease. Lancet.     354:407-13.
  53. Folsom AR, et al. (1998). Prospective study of coronary heart disease incidence     in relation to fasting homocysteine, related polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. Circulation. 98:204-10.
  54. Fallon UB, et al. (2001). Homocysteine and coronary heart disease in the Caerphilly cohort: a 10-year follow up. Heart, 85:53-158.
  55. Higdon JV & Frei B. (2006). Coffee and Health: A Review of Recent Human     Research. Crit Revs Fd Sci Nutr, 46:101-23.
  56. Grubben MJ, et al. (2000). Unfiltered coffee increases plasma homocysteine     concentrations in healthy volunteers: a randomized trial. AJCN. 71:448-84.
  57. Urgert RA, et al. (2000). Heavy coffee consumption and plasma homocysteine: a     randomized controlled trial in healthy volunteers. AJCN. 72:1107-10.
  58. Christensen B, et al. (2001). Abstention from filtered coffee reduces concentrations of plasma homocysteine and serum cholesterol – a randomized controlled trial. AJCN. 74(3):302-7.
  59. Espositio F, et al. (2003): Moderate coffee consumption increases plasma glutathione     but not homocysteine in healthy subjects. Aliment Pharmacol Therapy. 17:595-601.
  60. Verhoef P, et al. (2002). Contribution of caffeine to the homocysteine-raising  effect of coffee: a randomized controlled trial in humans. AJCN. 76:1244-8.
  61. Olthof MR, et al. (2001). Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. AJCN. 7(737):532-8.
  62. Zhang W, et al. (2009). Coffee consumption and risk of cardiovascular disease and all-cause mortality among men with type 2 diabetes. Diabetes Care. 32:1043-5.
  63. Mukanal KJ, et al. (2009): Coffee consumption and mortality after acute myocardial infarction: the Stockholm Heart Epidemiology Program. Am Heart J. 157:495-501.
  64. Palatini P, et al. (2009). CYP1A2 genotype modifies the association between coffee     intake and the risk of hypertension. J Hypertension. 27(8):1594-601.
  65. Lopez-Garcia E, et al. (2016). Habitual coffee consumption and 24-hour blood pressure     control in older adults with hypertension. Clin Nutr. 35(6):1457-63.
  66. Notara V, et al. (2015). The role of coffee consumption on the 10-year (2004-2014) Acute Coronary Syndrome (ACS) Incidence among cardiac patients: the GREECS observational study. Int J Fd Sci & Nutr. 66(6):722-8.
  67. Brown OI, et al. (2016). Coffee reduces the risk of death after acute myocardial infarction: a meta-analysis. Coron Artery Dis. 27(7):566-72.
  68. Chrysant SG. (2017). The impact of coffee consumption on blood pressure,     cardiovascular disease and diabetes mellitus. Exp Rev Cardiovasc Thera. 15(3):151-6.
  69. Kastorini CM, et al. (2009). Moderate coffee consumption lowers the likelihood of developing  left ventricular systolic dysfunction in post-acute coronary syndrome     normotensive patients. J Med Food, 12(1):29-36.
  70. Richardson T, et al. (2009). Randomized control trials investigating the influence of     coffee on heart rate variability in patients with ST-segment elevation myocardial infarction. Q J Med, 102(8):555-61.
  71. Namdar M, et al. (2009): Caffeine impairs myocardial blood flow response to physical exercise in patients with artery disease as well as in age-matched controls. PloS ONE. 4(5):e5665.
  72. Shechter M, et al. (2011). Impact of acute caffeine ingestion on endothelial function in subjects with and without coronary artery disease. Am J Cardiol, 107(9):1255-61.
  73. Townsend N, et al. (2016). Cardiovascular disease in Europe: epidemiological update     2016.Eur Heart J. 0, 1-14.
  74. European  Heart Network, ‘European Cardiovascular Disease Statistics 2017’. Available at: http://www.ehnheart.org/cvd-statistics/cvd-statistics-2017.html.
  75. van Dam R. (2008). Combined impact of lifestyle factors on mortality: prospective cohort study in US women. BMJ. 337:a1440.
  76. Mozaffarian D, et al. (2008): Beyond established and novel risk factors: lifestyle risk factors for cardiovascular disease. Circ. 117(23):3031-8.
  77. Natella F, et al. (2002): Coffee drinking influences plasma antioxidant capacity in humans. Food Chem. 50:6211-6.
  78. Williamson G. (2017): The role of polyphenols in modern nutrition. Nutr Bull. 42(3):226-35.

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