- Intervention studies have shown that high levels of coffee consumption(6-10 cups of coffee per day) increase tHCYs32,33, and tHCYs decrease if regular coffee consumers stop drinking coffee34
- However, a study based on 5 cups of espresso a day did not show a significant effect on tHCYs, possibly because of the smaller volume consumed35
- It has been suggested that caffeine may be partly responsible for the effect of coffee on tHCYs36, but the presence of chlorogenic acid in coffee can also contribute to the effect on homocysteine37