Coffee and blood homocysteine

• Intervention studies have shown that high levels of coffee consumption(6-10 cups of coffee per day) increase tHCYs^32,33, and tHCYs decrease if regular coffee consumers stop drinking coffee³⁴‍
• However, a study based on 5 cups of espresso a day did not show a significant effect on tHCYs, possibly because of the smaller volume consumed³⁵

• It has been suggested that caffeine may be partly responsible for the effect of coffee on tHCYs³⁶, but the presence of chlorogenic acid in coffee can also contribute to the effect on homocysteine³⁷

‍