Turati F, et al (2010). Coffee and cancers of the upper digestive and respiratory tracts: meta-analyses of observational studies. Ann Oncol; 22(3):536-544.Print this page
Data of epidemiological studies on the relation between coffee drinking and upper aerodigestive tract cancer risk are scattered and inconclusive. We therefore conducted systematic meta-analyses of observational studies published before October 2009.
Materials and methods
We combined relative risks (RR) with 95% confidence intervals (CI) for cancers of the oral cavity/pharynx (OP) and larynx, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), comparing the highest versus the lowest categories of coffee consumption, using random-effects models.
For OP cancer, the pooled RR was 0.64 (95% CI 0.51–0.80) for highest versus lowest coffee drinking, based on a total of 2633 cases from one cohort and eight case–control studies, with no significant heterogeneity across studies. The RRs were 0.61 (95% CI 0.41–0.89) for European, 0.58 (95% CI 0.36–0.94) for American and 0.74 (95% CI 0.48–1.15) for Asian studies, where coffee consumption is lower. The corresponding RRs were 1.56 (95% CI 0.60–4.02) for laryngeal cancer (732 cases from three case–control studies), 0.87 (95% CI 0.65–1.17) for ESCC (2115 cases from one cohort and six case–control studies) and 1.18 (95% CI 0.81–1.71) for EAC (415 cases from three case–control studies).
Coffee drinking is inversely related to OP cancer risk, while there is no relation with laryngeal cancer, ESCC and EAC.
This information is intended for Healthcare professional audiences.
Please consider the environment before printing.