E Nakano et al, 2020. Relationship between intraocular pressure and coffee consumption in a Japanese population without glaucoma: The Nagahama study, Ophthalmology Glaucoma, published online.Print this page
To evaluate the association between daily coffee consumption and intraocular pressure (IOP) in healthy subjects without glaucoma and the association between daily coffee consumption and history of glaucoma.
A total of 9,850 individuals participated in the first follow-up of the Nagahama Prospective Cohort for Comprehensive Human Bioscience (the Nagahama study) conducted between 2013 to 2016.
All subjects underwent a standardized ophthalmic examination. Self-reporting questionnaires were completed by all participants. Firstly, the association between habitual coffee consumption and intraocular pressure (IOP) among non-glaucoma individuals was evaluated by a multivariable linear regression analysis, adjusting for possible confounders. Secondly, the association between habitual coffee consumption and history of glaucoma was also evaluated using a multivariable logistic regression analysis.
Main Outcome Measures:
The association between habitual coffee consumption and intraocular pressure (IOP) among non-glaucoma individuals.
Of 9,850 participants, 9,418 subjects did not have history of glaucoma. Among these subjects, the average IOP of both eyes was 14.7 ± 2.9 mmHg (mean ± standard deviation). The multivariable regression analysis revealed that habitual coffee consumption was significantly associated with IOP (p < 0.001): the higher the consumption of coffee, the lower the IOP of an individual. The IOP of the group that consumed coffee most frequently (more than or equal to three times a day) was 0.4 mmHg (95% confidence interval: 0.2 to 0.5mmHg) lower than that of the group that consumed coffee least frequently (less than once a day). On the other hand, the logistic regression analysis showed that habitual coffee consumption was not significantly associated with history of glaucoma (P=0.53).
Frequent coffee consumption was associated with a slightly lower IOP in people without glaucoma, but was not associated with a decreased risk of developing glaucoma. Additional experimental studies are needed to examine the effects of coffee on IOP and glaucoma risk.
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