E A Hu et al, 2018. Coffee consumption and liver-related hospitalizations and deaths in the ARIC study, European Journal of Clinical Nutrition, published online.Print this page
Coffee consumption has been found to be associated with reduced risk of chronic conditions such as liver disease. However, less is known about the association between coffee and liver-related hospitalizations and deaths.
We conduct ed a prospective analysis on 14,208 participants aged 45–64 years from the Atherosclerosis Risk in Communities (ARIC) study. Coffee consumption (cups/day) was assessed using food frequency questionnaires at visit 1 (1987–89) and visit 3 (1993–95). Liver-related hospitalizations were deﬁned as a hospitalization with any International Classiﬁcation of Diseases, Ninth Revision (ICD-9) code related to liver disease identiﬁed through cohort surveillance. Liver-related death was deﬁned as any death with a liver disease ICD-9 code listed anywhere on the death certiﬁcate form.
There were 833 incident cases of liver-related hospitalizations over a median follow-up of 24 years and 152 liver-related deaths over a median follow-up of 25 years. Participants who were in the highest category of coffee consumption (≥ 3cups/day) were more likely to be men, whites, current smokers, and current alcohol drinkers. In our fully adjusted model ,consuming ≥ 3 cups/day of coffee was signiﬁcantly associated with a reduced risk of liver-related hospitalizations compared with never drinkers (hazard ratio: 0.79, 95% CI: 0.63–0.99). There were no signiﬁcant associations between coffee consumption and liver-related deaths after adjusting for covariates.
Coffee drinkers may be at lower risk for liver-related hospitalizations. This supports current evidence that low and moderate levels of coffee may be protective to the liver.
This information is intended for Healthcare professional audiences.
Please consider the environment before printing.