S Rautiainen et al, 2012. Total Antioxidant Capacity from Diet and Risk of Myocardial Infarction: A Prospective Cohort of Women, The American Journal of Medicine, Volume 125.

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BACKGROUND: There are no previous studies investigating the effect of all dietary antioxidants in relation
to myocardial infarction. The total antioxidant capacity of diet takes into account all antioxidants and
synergistic effects between them. The aim of this study was to examine how total antioxidant capacity of
diet and antioxidant-containing foods were associated with incident myocardial infarction among middleaged
and elderly women.
METHODS: In the population-based prospective Swedish Mammography Cohort of 49-83-year-old women,
32,561 were cardiovascular disease-free at baseline. Women completed a food-frequency questionnaire,
and dietary total antioxidant capacity was calculated using oxygen radical absorbance capacity values.
Information on myocardial infarction was identified from the Swedish Hospital Discharge and the Cause
of Death registries. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox
proportional hazard models.
RESULTS: During the follow-up (September 1997-December 2007), we identified 1114 incident cases of
myocardial infarction (321,434 person-years). In multivariable-adjusted analysis, the HR for women
comparing the highest quintile of dietary total antioxidant capacity to the lowest was 0.80 (95% CI,
0.67-0.97; P for trend = 0.02). Servings of fruit and vegetables and whole grains were nonsignificantly
inversely associated with myocardial infarction.
CONCLUSIONS: These data suggest that dietary total antioxidant capacity, based on fruits, vegetables,
coffee, and whole grains, is of importance in the prevention of myocardial infarction.
© 2012 Elsevier Inc. All rights reserved. • The American Journal of Medicine (2012) 125, 974-980

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