M Shechter et al. (2011), Impact of acute caffeine ingestion on endothelial function in subjects with and without coronary artery disease, American Journal of Cardiology, 107(9):1255-61.

Print this page

Although coffee is a widely used, pharmacologically active beverage, its impact on the cardiovascular system is controversial. To explore the effect of acute caffeine ingestion on brachial artery flow-mediated dilation (FMD) in subjects without coronary artery disease (CAD; controls) and patients with CAD, we prospectively assessed brachial artery FMD in 40 controls and 40 age- and gender-matched patients with documented stable CAD on 2 separate mornings 1 week to 2 weeks apart. After overnight fasting, discontinuation of all medications for ≥12 hours, and absence of caffeine for >48 hours, participants received capsules with caffeine 200 mg or placebo. One hour after drug ingestion, participants underwent brachial artery FMD and nitroglycerin-mediated dilation (NTG) using high-resolution ultrasound. As expected, patients with CAD were more oftein diabetic, hypertensive, obese, dyslipidemic, and smoked more than controls (p

This information is intended for Healthcare professional audiences.
Please consider the environment before printing.